Hematologic profiles of Beta thalassemia major patients: An institutional cross-sectional study

Introduction: Thalassemia is inherited blood disorder characterized by decreased hemoglobin with two main types-alpha and beta thalassemia. There are varieties of β thalassaemia, β0 in which no globin produced, β+ some but less than normal. As the patient diagnosed, regular transfusions chelating treatment given lifelong. In this study, we observed haematological profiles multi transfused thalassemia major patients accompanying complications.Aims Objectives: To study clinical features RBC parameters, serum ferritin levels, chelation therapy prevalence transfusion related infection patients.Materials Method: cross sectional total 90 diagnosed were taken their complete history, physical examination laboratory parameters such as- counts. All monitored for levels along screening transmitted infections over a year. data compiled appropriate statistical analysis was done.Results: present out patients, 54 males 36 females. Mean age 15.26 ± 7.04 years 68.9% (N=62) cases required twice monthly transfusion, 30.0% (n=27) once month transfusion. 25 found to be HCV+ (27.78%), 3 HIV + (3.3%) 62 n on-reactive (68.89%). On first post CBC that 30 (33.33%) adequately > 10 gm%, where as second results 34 (37.78%) >10 gm%. average yearly values duration 4724 287.65 ng/mL. The agent dose mean 1040 mg standard deviation 476.19.Conclusion: it concluded like Haematocrit, Red Blood Cell mass, Haemoglobin Corpuscular volume had large covariances Serum Ferritin positively correlated increased rate patients.